Nociceptin/orphanin FQ (N/OFQ) modulates immunopathology and airway hyperresponsiveness representing a novel target for the treatment of asthma

BACKGROUND AND PURPOSE: There is evidence supporting a role for the nociceptin/orphanin FQ (N/OFQ; NOP) receptor and its endogenous ligand N/OFQ in the modulation of neurogenic inflammation, airway tone and calibre. We hypothesized that NOP receptor activation has beneficial effects upon asthma immu...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Br J Pharmacol
Main Authors: Singh, Shailendra R, Sullo, Nikol, Matteis, Maria, Spaziano, Giuseppe, McDonald, John, Saunders, Ruth, Woodman, Lucy, Urbanek, Konrad, De Angelis, Antonella, De Palma, Raffaele, Berair, Rachid, Pancholi, Mitesh, Mistry, Vijay, Rossi, Francesco, Guerrini, Remo, Calò, Girolamo, D'Agostino, Bruno, Brightling, Christopher E, Lambert, David G
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2016
Assuntos:
Research Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4940820/
https://ncbi.nlm.nih.gov/pubmed/26756419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13416
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares