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Detecting moxifloxacin‐induced QTc prolongation in thorough QT and early clinical phase studies using a highly automated ECG analysis approach
BACKGROUND AND PURPOSE: Exposure–response (ER) modelling (concentration–QTc analysis) is gaining as much acceptance as the traditional by‐time analysis of the placebo‐adjusted change from baseline in the QTc interval (ΔΔQTcF). It has been postulated that intensive ECG analysis and ER modelling durin...
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| Publicado no: | Br J Pharmacol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4940819/ https://ncbi.nlm.nih.gov/pubmed/26784016 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13436 |
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