Detecting moxifloxacin‐induced QTc prolongation in thorough QT and early clinical phase studies using a highly automated ECG analysis approach

BACKGROUND AND PURPOSE: Exposure–response (ER) modelling (concentration–QTc analysis) is gaining as much acceptance as the traditional by‐time analysis of the placebo‐adjusted change from baseline in the QTc interval (ΔΔQTcF). It has been postulated that intensive ECG analysis and ER modelling durin...

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Udgivet i:Br J Pharmacol
Main Authors: Panicker, Gopi Krishna, Karnad, Dilip R, Kadam, Pramod, Badilini, Fabio, Damle, Anil, Kothari, Snehal
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2016
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4940819/
https://ncbi.nlm.nih.gov/pubmed/26784016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13436
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