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Are women more susceptible than men to drug-induced QT prolongation? Concentration-QT(c) modelling in a phase 1 study with oral rac-sotalol
AIM: To study the differences in QT(c) interval on ECG in response to a single oral dose of rac-sotalol in men and women. METHODS: Continuous 12-lead ECGs were recorded in 28 men and 11 women on a separate baseline day and following a single oral dose of 160 mg rac-sotalol on the following day. ECGs...
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| Publicado no: | Br J Clin Pharmacol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4371537/ https://ncbi.nlm.nih.gov/pubmed/23819796 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12201 |
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