Are women more susceptible than men to drug-induced QT prolongation? Concentration-QT(c) modelling in a phase 1 study with oral rac-sotalol

AIM: To study the differences in QT(c) interval on ECG in response to a single oral dose of rac-sotalol in men and women. METHODS: Continuous 12-lead ECGs were recorded in 28 men and 11 women on a separate baseline day and following a single oral dose of 160 mg rac-sotalol on the following day. ECGs...

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Vydáno v:Br J Clin Pharmacol
Hlavní autoři: Darpo, Borje, Karnad, Dilip R, Badilini, Fabio, Florian, Jeff, Garnett, Christine E, Kothari, Snehal, Panicker, Gopi Krishna, Sarapa, Nenad
Médium: Artigo
Jazyk:Inglês
Vydáno: BlackWell Publishing Ltd 2014
Témata:
Pharmacokinetic Dynamic Relationships
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371537/
https://ncbi.nlm.nih.gov/pubmed/23819796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12201
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