Palindrome-Mediated Translocations in Humans: A New Mechanistic Model for Gross Chromosomal Rearrangements

Palindromic DNA sequences, which can form secondary structures, are widely distributed in the human genome. Although the nature of the secondary structure—single-stranded “hairpin” or double-stranded “cruciform”—has been extensively investigated in vitro, the existence of such unusual non-B DNA in v...

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Bibliographic Details
Published in:Front Genet
Main Authors: Inagaki, Hidehito, Kato, Takema, Tsutsumi, Makiko, Ouchi, Yuya, Ohye, Tamae, Kurahashi, Hiroki
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2016
Subjects:
Genetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4940405/
https://ncbi.nlm.nih.gov/pubmed/27462347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2016.00125
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