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Activation of SIRT3 by the NAD(+) precursor nicotinamide riboside protects from noise-induced hearing loss
Intense noise exposure causes hearing loss by inducing degeneration of spiral ganglia neurites that innervate cochlear hair cells. Nicotinamide adenine dinucleotide (NAD(+)) exhibits axon-protective effects in cultured neurons, however, its ability to block degeneration in vivo has been difficult to...
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| Veröffentlicht in: | Cell Metab |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4940130/ https://ncbi.nlm.nih.gov/pubmed/25470550 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.11.003 |
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