MYC Regulates the Anti-Tumor Immune Response through CD47 and PD-L1

The MYC oncogene codes for a transcription factor that is overexpressed in many human cancers. Here we show that MYC regulates the expression of two immune checkpoint proteins on the tumor cell surface, the innate immune regulator, CD47 (Cluster of Differentiation 47) and the adaptive immune checkpo...

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Publicat a:Science
Autors principals: Casey, Stephanie C., Tong, Ling, Li, Yulin, Do, Rachel, Walz, Susanne, Fitzgerald, Kelly N., Gouw, Arvin, Baylot, Virginie, Gutgemann, Ines, Eilers, Martin, Felsher, Dean W.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4940030/
https://ncbi.nlm.nih.gov/pubmed/26966191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aac9935
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