Luteinizing Hormone Causes Phosphorylation and Activation of the cGMP Phosphodiesterase PDE5 in Rat Ovarian Follicles, Contributing, Together with PDE1 Activity, to the Resumption of Meiosis

The meiotic cell cycle of mammalian oocytes in preovulatory follicles is held in prophase arrest by diffusion of cGMP from the surrounding granulosa cells into the oocyte. Luteinizing hormone (LH) then releases meiotic arrest by lowering cGMP in the granulosa cells. The LH-induced reduction of cGMP...

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Veröffentlicht in:Biol Reprod
Hauptverfasser: Egbert, Jeremy R., Uliasz, Tracy F., Shuhaibar, Leia C., Geerts, Andreas, Wunder, Frank, Kleiman, Robin J., Humphrey, John M., Lampe, Paul D., Artemyev, Nikolai O., Rybalkin, Sergei D., Beavo, Joseph A., Movsesian, Matthew A., Jaffe, Laurinda A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for the Study of Reproduction, Inc. 2016
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4939740/
https://ncbi.nlm.nih.gov/pubmed/27009040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1095/biolreprod.115.135897
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