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Investigating Therapeutic Protein Structure with Diethylpyro-carbonate Labeling and Mass Spectrometry

Protein therapeutics are rapidly transforming the pharmaceutical industry. Unlike for small molecule therapeutics, current technologies are challenged to provide the rapid, high resolution analyses of protein higher order structures needed to ensure drug efficacy and safety. Consequently, significan...

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Detalhes bibliográficos
Publicado no:Anal Chem
Main Authors: Borotto, Nicholas B., Zhou, Yuping, Hollingsworth, Stephen R., Hale, John E., Graban, Eric M., Vaughan, Robert C., Vachet, Richard W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4939621/
https://ncbi.nlm.nih.gov/pubmed/26399599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.5b03180
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