Whole genome amplification from a single cell: implications for genetic analysis.

We have developed an in vitro method for amplifying a large fraction of the DNA sequences present in a single haploid cell by repeated primer extensions using a mixture of 15-base random oligonucleotides. We studied 12 genetic loci and estimate that the probability of amplifying any sequence in the...

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Библиографические подробности
Главные авторы: Zhang, L, Cui, X, Schmitt, K, Hubert, R, Navidi, W, Arnheim, N
Формат: Artigo
Язык:Inglês
Опубликовано: 1992
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC49394/
https://ncbi.nlm.nih.gov/pubmed/1631067
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