Febuxostat, a novel xanthine oxidoreductase inhibitor, improves hypertension and endothelial dysfunction in spontaneously hypertensive rats

Xanthine oxidase (XO) is an enzyme responsible for the production of uric acid. XO produces considerable amount of oxidative stress throughout the body. To date, however, its pathophysiologic role in hypertension and endothelial dysfunction still remains controversial. To explore the possible involv...

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Bibliographic Details
Published in:Naunyn Schmiedebergs Arch Pharmacol
Main Authors: Shirakura, Takashi, Nomura, Johji, Matsui, Chieko, Kobayashi, Tsunefumi, Tamura, Mizuho, Masuzaki, Hiroaki
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2016
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4939152/
https://ncbi.nlm.nih.gov/pubmed/27198514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00210-016-1239-1
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