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Dissecting dynamic allosteric pathways using chemically related small molecule activators
The allosteric mechanism of the heterodimeric enzyme imidazole glycerol phosphate synthase was studied in detail with solution NMR spectroscopy and molecular dynamics simulations. We studied IGPS in complex with a series of allosteric activators corresponding to a large range of catalytic rate enhan...
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| Vydáno v: | Structure |
|---|---|
| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2016
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4938718/ https://ncbi.nlm.nih.gov/pubmed/27238967 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.04.010 |
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