Transgenic antigen-specific, HLA-A*02:01-allo-restricted cytotoxic T cells recognize tumor-associated target antigen STEAP1 with high specificity

Pediatric cancers, including Ewing sarcoma (ES), are only weakly immunogenic and the tumor-patients' immune system often is devoid of effector T cells for tumor elimination. Based on expression profiling technology, targetable tumor-associated antigens (TAA) are identified and exploited for eng...

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Dettagli Bibliografici
Pubblicato in:Oncoimmunology
Autori principali: Schirmer, David, Grünewald, Thomas G. P., Klar, Richard, Schmidt, Oxana, Wohlleber, Dirk, Rubío, Rebeca Alba, Uckert, Wolfgang, Thiel, Uwe, Bohne, Felix, Busch, Dirk H., Krackhardt, Angela M., Burdach, Stefan, Richter, Günther H. S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2016
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4938321/
https://ncbi.nlm.nih.gov/pubmed/27471654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1175795
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