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Residue contacts predicted by evolutionary covariance extend the application of ab initio molecular replacement to larger and more challenging protein folds

For many protein families, the deluge of new sequence information together with new statistical protocols now allow the accurate prediction of contacting residues from sequence information alone. This offers the possibility of more accurate ab initio (non-homology-based) structure prediction. Such m...

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Vydáno v:IUCrJ
Hlavní autoři: Simkovic, Felix, Thomas, Jens M. H., Keegan, Ronan M., Winn, Martyn D., Mayans, Olga, Rigden, Daniel J.
Médium: Artigo
Jazyk:Inglês
Vydáno: International Union of Crystallography 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4937781/
https://ncbi.nlm.nih.gov/pubmed/27437113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2052252516008113
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