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Residue contacts predicted by evolutionary covariance extend the application of ab initio molecular replacement to larger and more challenging protein folds

For many protein families, the deluge of new sequence information together with new statistical protocols now allow the accurate prediction of contacting residues from sequence information alone. This offers the possibility of more accurate ab initio (non-homology-based) structure prediction. Such m...

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Detalhes bibliográficos
Publicado no:IUCrJ
Main Authors: Simkovic, Felix, Thomas, Jens M. H., Keegan, Ronan M., Winn, Martyn D., Mayans, Olga, Rigden, Daniel J.
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4937781/
https://ncbi.nlm.nih.gov/pubmed/27437113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2052252516008113
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