Ensembles generated from crystal structures of single distant homologues solve challenging molecular-replacement cases in AMPLE

Molecular replacement (MR) is the predominant route to solution of the phase problem in macromolecular crystallography. Although routine in many cases, it becomes more effortful and often impossible when the available experimental structures typically used as search models are only distantly homolog...

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Bibliographic Details
Published in:Acta Crystallogr D Struct Biol
Main Authors: Rigden, Daniel J., Thomas, Jens M. H., Simkovic, Felix, Simpkin, Adam, Winn, Martyn D., Mayans, Olga, Keegan, Ronan M.
Format: Artigo
Language:Inglês
Published: International Union of Crystallography 2018
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Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5947759/
https://ncbi.nlm.nih.gov/pubmed/29533226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2059798318002310
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