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Selection and explosive growth alter genetic architecture and hamper the detection of causal rare variants
The role of rare alleles in complex phenotypes has been hotly debated, but most rare variant association tests (RVATs) do not account for the evolutionary forces that affect genetic architecture. Here, we use simulation and numerical algorithms to show that explosive population growth, as experience...
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| Publicado no: | Genome Res |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4937562/ https://ncbi.nlm.nih.gov/pubmed/27197206 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.202440.115 |
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