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The structure of ends determines the pathway choice and Mre11 nuclease dependency of DNA double-strand break repair
The key event in the choice of repair pathways for DNA double-strand breaks (DSBs) is the initial processing of ends. Non-homologous end joining (NHEJ) involves limited processing, but homology-dependent repair (HDR) requires extensive resection of the 5′ strand. How cells decide if an end is channe...
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| Gepubliceerd in: | Nucleic Acids Res |
|---|---|
| Hoofdauteurs: | , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Oxford University Press
2016
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4937313/ https://ncbi.nlm.nih.gov/pubmed/27084932 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw274 |
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