Can Ketones Help Rescue Brain Fuel Supply in Later Life? Implications for Cognitive Health during Aging and the Treatment of Alzheimer’s Disease

We propose that brain energy deficit is an important pre-symptomatic feature of Alzheimer’s disease (AD) that requires closer attention in the development of AD therapeutics. Our rationale is fourfold: (i) Glucose uptake is lower in the frontal cortex of people >65 years-old despite cognitive sco...

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Bibliografske podrobnosti
izdano v:Front Mol Neurosci
Main Authors: Cunnane, Stephen C., Courchesne-Loyer, Alexandre, Vandenberghe, Camille, St-Pierre, Valérie, Fortier, Mélanie, Hennebelle, Marie, Croteau, Etienne, Bocti, Christian, Fulop, Tamas, Castellano, Christian-Alexandre
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2016
Teme:
Neuroscience
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4937039/
https://ncbi.nlm.nih.gov/pubmed/27458340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2016.00053
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