Obesity promotes PhIP-induced small intestinal carcinogenesis in hCYP1A-db/db mice: involvement of mutations and DNA hypermethylation of Apc

Obesity is associated with an increased risk of cancer. To study the promotion of dietary carcinogen-induced gastrointestinal cancer by obesity, we employed 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) to induce intestinal tumorigenesis in CYP1A-humanized (hCYP1A) mice, in which mouse Cyp1...

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Bibliografiske detaljer
Udgivet i:Carcinogenesis
Main Authors: Wang, Hong, Liu, Anna, Kuo, Yingyi, Chi, Eric, Yang, Xu, Zhang, Lanjing, Yang, Chung S.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
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Original Manuscript
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4936388/
https://ncbi.nlm.nih.gov/pubmed/27207656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgw054
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