Broad Cross-Protection Is Induced in Preclinical Models by a Human Papillomavirus Vaccine Composed of L1/L2 Chimeric Virus-Like Particles

At least 15 high-risk human papillomaviruses (HPVs) are linked to anogenital preneoplastic lesions and cancer. Currently, there are three licensed prophylactic HPV vaccines based on virus-like particles (VLPs) of the L1 major capsid protein from HPV-2, -4, or -9, including the AS04-adjuvanted HPV-16...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Boxus, Mathieu, Fochesato, Michel, Miseur, Agnès, Mertens, Emmanuel, Dendouga, Najoua, Brendle, Sarah, Balogh, Karla K., Christensen, Neil D., Giannini, Sandra L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2016
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4936133/
https://ncbi.nlm.nih.gov/pubmed/27147749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00449-16
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