Monoclonal Antibodies to Different Components of the Human Cytomegalovirus (HCMV) Pentamer gH/gL/pUL128L and Trimer gH/gL/gO as well as Antibodies Elicited during Primary HCMV Infection Prevent Epithelial Cell Syncytium Formation

Human cytomegalovirus (HCMV) may cause disseminated/end-organ disease in congenitally infected newborns and immunosuppressed transplant recipients. Two glycoprotein complexes, gH/gL/gO and gH/gL/pUL128/pUL130/pUL131 (gH/gL/pUL128L; referred to as the pentamer), are required for HCMV entry into fibro...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Gerna, Giuseppe, Percivalle, Elena, Perez, Laurent, Lanzavecchia, Antonio, Lilleri, Daniele
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2016
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4936130/
https://ncbi.nlm.nih.gov/pubmed/27122579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00121-16
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