Targeting Focal Adhesion Kinase Renders Pancreatic Cancers Responsive to Checkpoint Immunotherapy

Single-agent immunotherapy has achieved limited clinical benefit to date in patients suffering from pancreatic ductal adenocarcinoma (PDAC). This may be due to the presence of a uniquely immunosuppressive tumor microenvironment (TME). Critical obstacles to immunotherapy in PDAC tumors include a high...

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Udgivet i:Nat Med
Main Authors: Jiang, Hong, Hegde, Samarth, Knolhoff, Brett L., Zhu, Yu, Herndon, John M., Meyer, Melissa A., Nywening, Timothy M., Hawkins, William G., Shapiro, Irina M., Weaver, David T., Pachter, Jonathan A., Wang-Gillam, Andrea, DeNardo, David G.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935930/
https://ncbi.nlm.nih.gov/pubmed/27376576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4123
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