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In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome

Accurate diagnosis of predisposition to long QT syndrome is crucial for reducing the risk of cardiac arrhythmias. In recent years, drug-induced provocative tests have proved useful to unmask some latent mutations linked to cardiac arrhythmias. In this study we expanded this concept by developing a p...

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Publicat a:J Mol Cell Cardiol
Autors principals: Romero, Lucia, Trenor, Beatriz, Yang, Pei-Chi, Saiz, Javier, Clancy, Colleen E.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935925/
https://ncbi.nlm.nih.gov/pubmed/26859003
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