Conditional ablation of myeloid TNF increases lesion volume after experimental stroke in mice, possibly via altered ERK1/2 signaling

Microglia are activated following cerebral ischemia and increase their production of the neuro- and immunomodulatory cytokine tumor necrosis factor (TNF). To address the function of TNF from this cellular source in focal cerebral ischemia we used TNF conditional knock out mice (LysMcreTNF(fl/fl)) in...

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Publicado no:Sci Rep
Main Authors: Clausen, Bettina Hjelm, Degn, Matilda, Sivasaravanaparan, Mithula, Fogtmann, Torben, Andersen, Maria Gammelstrup, Trojanowsky, Michelle D., Gao, Han, Hvidsten, Svend, Baun, Christina, Deierborg, Tomas, Finsen, Bente, Kristensen, Bjarne Winther, Bak, Sara Thornby, Meyer, Morten, Lee, Jae, Nedospasov, Sergei A., Brambilla, Roberta, Lambertsen, Kate Lykke
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935869/
https://ncbi.nlm.nih.gov/pubmed/27384243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29291
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