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Total Synthesis of (+)-SCH 351448: Efficiency via Chemoselectivity and Redox-Economy Powered by Metal Catalysis

The polyketide natural product (+)-SCH 351448, a macrodiolide ionophore bearing 14 stereogenic centers, is prepared in 14 steps (LLS). In 8 prior syntheses, 22–32 steps were required. Multiple chemoselective and redox-economic functional group interconversions collectively contribute to a step-chang...

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Bibliografische gegevens
Gepubliceerd in:J Am Chem Soc
Hoofdauteurs: Wang, Gang, Krische, Michael J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935581/
https://ncbi.nlm.nih.gov/pubmed/27337561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b04917
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