Two ways to skin a cat: ADEP antibiotics can kill bacteria through activation or inhibition of ClpP activity

Lignende værker

• The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease
  af: Kirstein, Janine, et al.
  Udgivet: (2009)
• Ureadepsipeptides as ClpP Activators
  af: Griffith, Elizabeth C., et al.
  Udgivet: (2019)
• The ADEP Biosynthetic Gene Cluster in Streptomyces hawaiiensis NRRL 15010 Reveals an Accessory clpP Gene as a Novel Antibiotic Resistance Factor
  af: Thomy, Dhana, et al.
  Udgivet: (2019)
• Acyldepsipeptide antibiotics kill mycobacteria by preventing the physiological functions of the ClpP1P2 protease
  af: Famulla, Kirsten, et al.
  Udgivet: (2016)
• Killing persister cells and eradicating a biofilm infection by activating the ClpP protease
  af: Conlon, BP, et al.
  Udgivet: (2013)