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Leptin receptor null mice with reexpression of LepR in GnRHR expressing cells display elevated FSH levels but remain in a prepubertal state

Leptin signals energy sufficiency to the reproductive hypothalamic-pituitary-gonadal (HPG) axis. Studies using genetic models have demonstrated that hypothalamic neurons are major players mediating these effects. Leptin receptor (LepR) is also expressed in the pituitary gland and in the gonads, but...

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Detalhes bibliográficos
Publicado no:Am J Physiol Regul Integr Comp Physiol
Main Authors: Allen, Susan J., Garcia-Galiano, David, Borges, Beatriz C., Burger, Laura L., Boehm, Ulrich, Elias, Carol F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935496/
https://ncbi.nlm.nih.gov/pubmed/27101301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00529.2015
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