p38 MAPK α and β isoforms differentially regulate plasma membrane localization of MRP2

In hepatocytes, cAMP both activates p38 mitogen-activated protein kinase (MAPK) and increases the amount of multidrug resistance-associated protein-2 (MRP2) in the plasma membrane (PM-MRP2). Paradoxically, taurolithocholate (TLC) activates p38 MAPK but decreases PM-MRP2 in hepatocytes. These opposin...

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Bibliographic Details
Published in:Am J Physiol Gastrointest Liver Physiol
Main Authors: Schonhoff, Christopher M., Park, Se Won, Webster, Cynthia R.L., Anwer, M. Sawkat
Format: Artigo
Language:Inglês
Published: American Physiological Society 2016
Subjects:
Liver and Biliary Tract Physiology/Pathophysiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935486/
https://ncbi.nlm.nih.gov/pubmed/27012769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00005.2016
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