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cAMP-GEF cytoprotection by Src tyrosine kinase activation of phosphoinositide-3-kinase p110 β/α in rat hepatocytes

Cyclic AMP protects against hepatocyte apoptosis by a protein kinase A-independent cAMP-GEF/phosphoinositide-3-kinase (PI3K)/Akt signaling pathway. However, the signaling pathway coupling cAMP-GEF with PI3K is unknown. The aim of this study was to investigate the role of Src tyrosine kinases (Src-TY...

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Bibliografische gegevens
Hoofdauteurs: Gates, Anna, Hohenester, Simon, Anwer, M. Sawkat, Webster, Cynthia R. L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Physiological Society 2009
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670669/
https://ncbi.nlm.nih.gov/pubmed/19196950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.90622.2008
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