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Imbalanced Rab3D versus Rab27 increases cathepsin S secretion from lacrimal acini in a mouse model of Sjögren's Syndrome

The mechanism responsible for the altered spectrum of tear proteins secreted by lacrimal gland acinar cells (LGAC) in patients with Sjögren's Syndrome (SS) remains unknown. We have previously identified increased cathepsin S (CTSS) activity as a unique characteristic of tears of patients with S...

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Detalhes bibliográficos
Publicado no:Am J Physiol Cell Physiol
Main Authors: Meng, Zhen, Edman, Maria C., Hsueh, Pang-Yu, Chen, Chiao-Yu, Klinngam, Wannita, Tolmachova, Tanya, Okamoto, Curtis T., Hamm-Alvarez, Sarah F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935202/
https://ncbi.nlm.nih.gov/pubmed/27076615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00275.2015
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