Downregulation of LRRC8A protects human ovarian and alveolar carcinoma cells against Cisplatin-induced expression of p53, MDM2, p21(Waf1/Cip1), and Caspase-9/-3 activation

The leucine-rich repeat containing 8A (LRRC8A) protein is an essential component of the volume-sensitive organic anion channel (VSOAC), and using pharmacological anion channel inhibitors (NS3728, DIDS) and LRRC8A siRNA we have investigated its role in development of Cisplatin resistance in human ova...

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Veröffentlicht in:Am J Physiol Cell Physiol
Hauptverfasser: Sørensen, Belinda Halling, Nielsen, Dorthe, Thorsteinsdottir, Unnur Arna, Hoffmann, Else Kay, Lambert, Ian Henry
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935196/
https://ncbi.nlm.nih.gov/pubmed/26984736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00256.2015
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