Phosphodiesterase 5 inhibitors augment UT-15C-stimulated ATP release from erythrocytes of humans with pulmonary arterial hypertension

Both prostacyclin analogs and phosphodiesterase 5 (PDE5) inhibitors are effective treatments for pulmonary arterial hypertension (PAH). In addition to direct effects on vascular smooth muscle, prostacyclin analogs increase cAMP levels and ATP release from healthy human erythrocytes. We hypothesized...

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Detalhes bibliográficos
Publicado no:Exp Biol Med (Maywood)
Main Authors: Bowles, Elizabeth A, Moody, Gina N, Yeragunta, Yashaswini, Stephenson, Alan H, Ellsworth, Mary L, Sprague, Randy S
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935182/
https://ncbi.nlm.nih.gov/pubmed/25125498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1535370214547155
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