Increased ADAMTS1 mediates SPARC-dependent collagen deposition in the aging myocardium

Secreted protein acidic and rich in cysteine (SPARC) is a collagen-binding matricellular protein highly expressed during fibrosis. Fibrosis is a prominent component of cardiac aging that reduces myocardial elasticity. Previously, we reported that SPARC deletion attenuated myocardial stiffness and co...

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Detalhes bibliográficos
Publicado no:Am J Physiol Endocrinol Metab
Main Authors: Toba, Hiroe, de Castro Brás, Lisandra E., Baicu, Catalin F., Zile, Michael R., Lindsey, Merry L., Bradshaw, Amy D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2016
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Call for Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935141/
https://ncbi.nlm.nih.gov/pubmed/27143554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00040.2016
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