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Plasma amino acid and metabolite signatures tracking diabetes progression in the UCD-T2DM rat model

Elevations of plasma concentrations of branched-chain amino acids (BCAAs) are observed in human insulin resistance and type 2 diabetes mellitus (T2DM); however, there has been some controversy with respect to the passive or causative nature of the BCAA phenotype. Using untargeted metabolomics, plasm...

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Detalhes bibliográficos
Publicado no:Am J Physiol Endocrinol Metab
Main Authors: Piccolo, Brian D., Graham, James L., Stanhope, Kimber L., Fiehn, Oliver, Havel, Peter J., Adams, Sean H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935135/
https://ncbi.nlm.nih.gov/pubmed/27094034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00052.2016
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