Plasma amino acid and metabolite signatures tracking diabetes progression in the UCD-T2DM rat model

Elevations of plasma concentrations of branched-chain amino acids (BCAAs) are observed in human insulin resistance and type 2 diabetes mellitus (T2DM); however, there has been some controversy with respect to the passive or causative nature of the BCAA phenotype. Using untargeted metabolomics, plasm...

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Veröffentlicht in:Am J Physiol Endocrinol Metab
Hauptverfasser: Piccolo, Brian D., Graham, James L., Stanhope, Kimber L., Fiehn, Oliver, Havel, Peter J., Adams, Sean H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2016
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935135/
https://ncbi.nlm.nih.gov/pubmed/27094034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00052.2016
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