Subcutaneous administration of leptin normalizes fasting plasma glucose in obese type 2 diabetic UCD-T2DM rats

Leptin has been shown to reduce hyperglycemia in rodent models of type 1 diabetes. We investigated the effects of leptin administration in University of California, Davis, type 2 diabetes mellitus (UCD-T2DM) rats, which develop adult-onset polygenic obesity and type 2 diabetes. Animals that had been...

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Bibliographic Details
Main Authors: Cummings, Bethany P., Bettaieb, Ahmed, Graham, James L., Stanhope, Kimber L., Dill, Riva, Morton, Gregory J., Haj, Fawaz G., Havel, Peter J.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2011
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3167517/
https://ncbi.nlm.nih.gov/pubmed/21873226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1107163108
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