Characterization of the Adeno-Associated Virus 1 and 6 Sialic Acid Binding Site

The adeno-associated viruses (AAVs), which are being developed as gene delivery vectors, display differential cell surface glycan binding and subsequent tissue tropisms. For AAV serotype 1 (AAV1), the first viral vector approved as a gene therapy treatment, and its closely related AAV6, sialic acid...

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Bibliographic Details
Published in:J Virol
Main Authors: Huang, Lin-Ya, Patel, Ami, Ng, Robert, Miller, Edward Blake, Halder, Sujata, McKenna, Robert, Asokan, Aravind, Agbandje-McKenna, Mavis
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4934739/
https://ncbi.nlm.nih.gov/pubmed/26962225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00161-16
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