Mutations in the Schmallenberg Virus Gc Glycoprotein Facilitate Cellular Protein Synthesis Shutoff and Restore Pathogenicity of NSs Deletion Mutants in Mice

Serial passage of viruses in cell culture has been traditionally used to attenuate virulence and identify determinants of viral pathogenesis. In a previous study, we found that a strain of Schmallenberg virus (SBV) serially passaged in tissue culture (termed SBVp32) unexpectedly displayed increased...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:J Virol
Κύριοι συγγραφείς: Varela, Mariana, Pinto, Rute Maria, Caporale, Marco, Piras, Ilaria M., Taggart, Aislynn, Seehusen, Frauke, Hahn, Kerstin, Janowicz, Anna, de Souza, William Marciel, Baumgärtner, Wolfgang, Shi, Xiaohong, Palmarini, Massimo
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Microbiology 2016
Θέματα:
Pathogenesis and Immunity
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4934738/
https://ncbi.nlm.nih.gov/pubmed/26984728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00424-16
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