Mutations in the Schmallenberg Virus Gc Glycoprotein Facilitate Cellular Protein Synthesis Shutoff and Restore Pathogenicity of NSs Deletion Mutants in Mice

Serial passage of viruses in cell culture has been traditionally used to attenuate virulence and identify determinants of viral pathogenesis. In a previous study, we found that a strain of Schmallenberg virus (SBV) serially passaged in tissue culture (termed SBVp32) unexpectedly displayed increased...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Varela, Mariana, Pinto, Rute Maria, Caporale, Marco, Piras, Ilaria M., Taggart, Aislynn, Seehusen, Frauke, Hahn, Kerstin, Janowicz, Anna, de Souza, William Marciel, Baumgärtner, Wolfgang, Shi, Xiaohong, Palmarini, Massimo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4934738/
https://ncbi.nlm.nih.gov/pubmed/26984728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00424-16
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