Accumulation of dipeptide repeat proteins predates that of TDP‐43 in frontotemporal lobar degeneration associated with hexanucleotide repeat expansions in C9ORF72 gene

AIMS: Frontotemporal lobar degeneration (FTLD) and motor neurone disease are linked by the possession of a hexanucleotide repeat expansion in C9ORF72, and both show neuronal cytoplasmic inclusions within cerebellar and hippocampal neurones which are TDP‐43 negative but immunoreactive for p62 and dip...

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Pubblicato in:Neuropathol Appl Neurobiol
Autori principali: Baborie, Atik, Griffiths, Timothy D., Jaros, Evelyn, Perry, Robert, McKeith, Ian G., Burn, David J., Masuda‐Suzukake, Masami, Hasegawa, Masato, Rollinson, Sara, Pickering‐Brown, Stuart, Robinson, Andrew C., Davidson, Yvonne S., Mann, David M. A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2015
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4934135/
https://ncbi.nlm.nih.gov/pubmed/25185840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nan.12178
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