Accumulation of dipeptide repeat proteins predates that of TDP‐43 in frontotemporal lobar degeneration associated with hexanucleotide repeat expansions in C9ORF72 gene

AIMS: Frontotemporal lobar degeneration (FTLD) and motor neurone disease are linked by the possession of a hexanucleotide repeat expansion in C9ORF72, and both show neuronal cytoplasmic inclusions within cerebellar and hippocampal neurones which are TDP‐43 negative but immunoreactive for p62 and dip...

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Detalhes bibliográficos
Publicado no:Neuropathol Appl Neurobiol
Main Authors: Baborie, Atik, Griffiths, Timothy D., Jaros, Evelyn, Perry, Robert, McKeith, Ian G., Burn, David J., Masuda‐Suzukake, Masami, Hasegawa, Masato, Rollinson, Sara, Pickering‐Brown, Stuart, Robinson, Andrew C., Davidson, Yvonne S., Mann, David M. A.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4934135/
https://ncbi.nlm.nih.gov/pubmed/25185840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nan.12178
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