Activation of p53 contributes to pseudolaric acid B-induced senescence in human lung cancer cells in vitro

AIM: Pseudolaric acid B (PAB), a diterpene acid isolated from the root bark of Pseudolarix kaempferi Gordon, has shown to exert anti-tumor effects via inducing cell cycle arrest followed by apoptosis in several cancer cell lines. Here we reported that PAB induced a mitotic catastrophe in human lung...

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Detalhes bibliográficos
Publicado no:Acta Pharmacol Sin
Main Authors: Yao, Guo-dong, Yang, Jing, Li, Qiang, Zhang, Ye, Qi, Min, Fan, Si-miao, Hayashi, Toshihiko, Tashiro, Shin-ichi, Onodera, Satoshi, Ikejima, Takashi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933766/
https://ncbi.nlm.nih.gov/pubmed/27041461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2016.8
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