Deterioration of autonomic neuronal receptor signaling and mechanisms intrinsic to heart pacemaker cells contribute to age‐associated alterations in heart rate variability in vivo

We aimed to determine how age‐associated changes in mechanisms extrinsic and intrinsic to pacemaker cells relate to basal beating interval variability (BIV) reduction in vivo. Beating intervals (BIs) were measured in aged (23–25 months) and adult (3–4 months) C57BL/6 male mice (i) via ECG in vivo du...

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Bibliographic Details
Published in:Aging Cell
Main Authors: Yaniv, Yael, Ahmet, Ismayil, Tsutsui, Kenta, Behar, Joachim, Moen, Jack M., Okamoto, Yosuke, Guiriba, Toni‐Rose, Liu, Jie, Bychkov, Rostislav, Lakatta, Edward G.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2016
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933656/
https://ncbi.nlm.nih.gov/pubmed/27168363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12483
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