A CD74-DEPENDENT MHC CLASS I ENDOLYSOSOMAL CROSS-PRESENTATION PATHWAY

Immune responses are initiated and primed by dendritic cells (DCs) that cross-present exogenous antigen. The CD74 (invariant chain) chaperone protein is thought to exclusively promote DC priming in the context of MHC class II. However, we demonstrate herein a CD74-dependent MHC class I cross-present...

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Udgivet i:Nat Immunol
Main Authors: Basha, Genc, Omilusik, Kyla, Chavez-Steenbock, Ana, Reinicke, Anna T., Lack, Nathan, Choi, Kyung Bok, Jefferies, Wilfred A.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933585/
https://ncbi.nlm.nih.gov/pubmed/22306692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2225
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