Phase II multicenter study of gene-mediated cytotoxic immunotherapy as adjuvant to surgical resection for newly diagnosed malignant glioma

BACKGROUND: Despite aggressive standard of care (SOC) treatment, survival of malignant gliomas remains very poor. This Phase II, prospective, matched controlled, multicenter trial was conducted to assess the safety and efficacy of aglatimagene besadenovec (AdV-tk) plus valacyclovir (gene-mediated cy...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Wheeler, Lee A., Manzanera, Andrea G., Bell, Susan D., Cavaliere, Robert, McGregor, John M., Grecula, John C., Newton, Herbert B., Lo, Simon S., Badie, Behnam, Portnow, Jana, Teh, Bin S., Trask, Todd W., Baskin, David S., New, Pamela Z., Aguilar, Laura K., Aguilar-Cordova, Estuardo, Chiocca, E. Antonio
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
Fag:
Clinical Investigations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933478/
https://ncbi.nlm.nih.gov/pubmed/26843484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now002
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