Phase II multicenter study of gene-mediated cytotoxic immunotherapy as adjuvant to surgical resection for newly diagnosed malignant glioma

BACKGROUND: Despite aggressive standard of care (SOC) treatment, survival of malignant gliomas remains very poor. This Phase II, prospective, matched controlled, multicenter trial was conducted to assess the safety and efficacy of aglatimagene besadenovec (AdV-tk) plus valacyclovir (gene-mediated cy...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Wheeler, Lee A., Manzanera, Andrea G., Bell, Susan D., Cavaliere, Robert, McGregor, John M., Grecula, John C., Newton, Herbert B., Lo, Simon S., Badie, Behnam, Portnow, Jana, Teh, Bin S., Trask, Todd W., Baskin, David S., New, Pamela Z., Aguilar, Laura K., Aguilar-Cordova, Estuardo, Chiocca, E. Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Clinical Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933478/
https://ncbi.nlm.nih.gov/pubmed/26843484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now002
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