Repurposing tromethamine as inhaled therapy to treat CF airway disease

In cystic fibrosis (CF), loss of CF transmembrane conductance regulator (CFTR) anion channel activity causes airway surface liquid (ASL) pH to become acidic, which impairs airway host defenses. One potential therapeutic approach is to correct the acidic pH in CF airways by aerosolizing HCO(3)(–) and...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Alaiwa, Mahmoud H. Abou, Launspach, Janice L., Sheets, Kelsey A., Rivera, Jade A., Gansemer, Nicholas D., Taft, Peter J., Thorne, Peter S., Welsh, Michael J., Stoltz, David A., Zabner, Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933331/
https://ncbi.nlm.nih.gov/pubmed/27390778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.87535
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