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pH modulates the activity and synergism of the airway surface liquid antimicrobials β-defensin-3 and LL-37

The pulmonary airways are continuously exposed to bacteria. As a first line of defense against infection, the airway surface liquid (ASL) contains a complex mixture of antimicrobial factors that kill inhaled and aspirated bacteria. The composition of ASL is critical for antimicrobial effectiveness....

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Abou Alaiwa, Mahmoud H., Reznikov, Leah R., Gansemer, Nicholas D., Sheets, Kelsey A., Horswill, Alexander R., Stoltz, David A., Zabner, Joseph, Welsh, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4284593/
https://ncbi.nlm.nih.gov/pubmed/25512526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1422091112
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