A Complex of Htm1 and the Oxidoreductase Pdi1 Accelerates Degradation of Misfolded Glycoproteins

A quality control system in the endoplasmic reticulum (ER) efficiently discriminates polypeptides that are in the process of productive folding from conformers that are trapped in an aberrant state. Only the latter are transported into the cytoplasm and degraded in a process termed ER-associated pro...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Pfeiffer, Anett, Stephanowitz, Heike, Krause, Eberhard, Volkwein, Corinna, Hirsch, Christian, Jarosch, Ernst, Sommer, Thomas
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
Subjects:
Protein Synthesis and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933269/
https://ncbi.nlm.nih.gov/pubmed/27053108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.703256
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