The Dynamics and Turnover of Tau Aggregates in Cultured Cells: INSIGHTS INTO THERAPIES FOR TAUOPATHIES

Filamentous tau aggregates, the hallmark lesions of Alzheimer disease (AD), play key roles in neurodegeneration. Activation of protein degradation systems has been proposed to be a potential strategy for removing pathological tau, but it remains unclear how effectively tau aggregates can be degraded...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Guo, Jing L., Buist, Arjan, Soares, Alberto, Callaerts, Kathleen, Calafate, Sara, Stevenaert, Frederik, Daniels, Joshua P., Zoll, Bryan E., Crowe, Alex, Brunden, Kurt R., Moechars, Diederik, Lee, Virginia M. Y.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Neurobiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933232/
https://ncbi.nlm.nih.gov/pubmed/27129267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.712083
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