Direct Binding to Replication Protein A (RPA)-coated Single-stranded DNA Allows Recruitment of the ATR Activator TopBP1 to Sites of DNA Damage

A critical event for the ability of cells to tolerate DNA damage and replication stress is activation of the ATR kinase. ATR activation is dependent on the BRCT (BRCA1 C terminus) repeat-containing protein TopBP1. Previous work has shown that recruitment of TopBP1 to sites of DNA damage and stalled...

Full description

Saved in:
Bibliographic Details
Published in:J Biol Chem
Main Authors: Acevedo, Julyana, Yan, Shan, Michael, W. Matthew
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
Subjects:
DNA and Chromosomes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933228/
https://ncbi.nlm.nih.gov/pubmed/27129245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.729194
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items